|Composition||Methylcobalamin 750mcg + 75mg Pregabalin|
|Indication||For In Allodynia associated Diabetic Peripheral Neuropathy.|
|Mechanism of Action||
Methylcobalamin: is used to prevent and treat low vitamin B12. Lack of vitamin B12 may cause anaemia and damage to the nerves. It is used to treat diabetic neuropathy and peripheral neuropathy. It is an essential nutrient that helps the body make healthy red blood and nerve cells.
Pregabalin:Pregabalin is an analogue of the neurotransmitter GABA. It binds potently to the α2-δ subunit resulting in modulation of Ca channels and reduction in the release of several neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, calcitonin gene-related peptide and substance P.
Absorption: Rapidly absorbed. Bioavailability: Approx 90%.
Time to peak plasma concentration: W/in 1.5 hr.
Distribution: Volume of distribution: 0.5 L/kg. Not bound to plasma protein.
Metabolism: Negligible metabolism.
Excretion: Via urine (approx. 98%) as unchanged drug).
Elimination half-life: 6.3 hr
Methylcobalamin: Anorexia, nausea, vomiting and diarrhoea. Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj. site Potentially Fatal: Anaphylactoid reactions (parenteral).
Somnolence, dizziness, headache, diplopia, blurred vision, vertigo, fatigue, irritability, arthralgia, muscle cramp, back and limb pain, cervical spasm, disorientation, insomnia, nasopharynges, ataxia, tremor, dysarthria, amnesia, paraesthesia, hypaesthesia, lethargy, sedation, oedema, peripheral oedema, dry mouth, constipation, diarrhoea, vomiting, nausea, flatulence, abdominal distension, increased appetite, wt. gain, euphoria, confusion, reduced libido, erectile dysfunction; attention, memory, coordination and gait disturbances; fall, feeling drunk, abnormal feeling. Rarely, Stevens-Johnson syndrome, rhabdomyolysis, breast enlargement, gynaecomastia.
Hypersensitivity or allergy to the ingredients Alpha Lipoic acid: In Pregnancy and lactation may lower blood glucose. Monitor blood glucose levels regularly.
May potentiate the effects of lorazepam. Additive CNS depressant effects w/ opiates and benzodiazepines. May increase risk of angioedema w/ ACE inhibitors. May increase risk of wt gain and peripheral oedema w/ thiazolidinedione’s.
Adult: Initially, 150 mg/day, may increase to 300 mg/day after 3-7 days. Max: 600 mg/day after a 7-day interval. All doses to be given in 2 or 3 divided doses.